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You are here:Home » Antibodies » Abs to Resistin » Anti -Resistin (RETN, RETN1, RSTN, Adipose Tissue-Specific Secretory Factor, ADSF, FIZZ3, Cysteine-rich Secreted Protein A12-alpha-like 2, Cysteine-Rich Secreted Protein FIZZ3, C/EBP-epsilon-Regulated Myeloid-Specific Secreted Cysteine-Rich Protein, HXCP1, RSTN

Anti -Resistin (RETN, RETN1, RSTN, Adipose Tissue-Specific Secretory Factor, ADSF, FIZZ3,
Cysteine-rich Secreted Protein A12-alpha-like 2, Cysteine-Rich Secreted Protein FIZZ3,
C/EBP-epsilon-Regulated Myeloid-Specific Secreted Cysteine-Rich Protein, HXCP1, RSTN

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
RELM:FIZZ family of proteins are Cysteine-rich proteins consist of a highly conserved C-terminal cysteine rich domain and play a vital role in regulation of adipogenesis and insulin resistance. Resistin, a human homolog of mouse resistin, is a novel member of this family. It is a 12kD adipokine which is produced by both brown and white adipose tissue and is mainly secreted by adipocytes. Its levels are down-regulated by insulin and have been shown to be elevated during Type 2 diabetes, indicating a critical role in regulating adipogenesis and insulin resistance. It promotes aortic smooth muscle cell proliferation through activation of ERK1:2 and PI3:Akt signaling pathways. It is expressed in macrophages and functions as a pro-inflammatory cytokine by up-regulating IL-6 and activating NF-kappaB signaling pathway. Its expression is regulated by numerous factors which include PPAR-alpha, Insulin, Growth and gonadal hormones, TNF-alpha, Endothelin-1 and certain pro-inflammatory cytokines like IL-6.
Catalog #R1585-02M
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa79-90 [GSWDVRAETTCH] of human Resistin.
SpecificityRecognizes human Resistin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCysteine-Rich Secreted Protein A12-alpha-Like 2, Found in Inflammatory Zone, MGC126603, MGC126609


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