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You are here:Home » Molecular Biology » MB-Resistin » Resistin-like Molecule, beta, Human (RELMb) (BSA Free)

Resistin-like Molecule, beta, Human (RELMb) (BSA Free)

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Specifications

Purified protein is a disulfide linked homodimer of ~19kD consisting of two 89-aa chains.
Resistance to insulin characterizes type 2 diabetes, the most common form of diabetes. There is a strong link between type 2 diabetes and obesity, as most patients tend to be obese. Thiozolidinediones (TZDs), a new class of anti-diabetic drugs, enhances target-tissue sensitivity to insulin. A screen of genes down regulated by TZD in adipocyte led to the discovery of a new protein hormone called resistin (for resistance to insulin). Resistin, specifically produced and secreted by adipocyte, is present at elevated levels in the blood of obese animals, and is down regulated by fasting and anti-diabetic drugs. Antibody to resistin stimulated glucose uptake and improved insulin sensitivity in obese mice. Some other protein related to resistin has been called resistin-related molecules (RELM-alpha and beta). Resistin family of proteins was also identified as proteins (FIZZ1-3, for Found in Inflammatory zone) involved in allergy and inflammation.
Catalog #R1587-24
RELM-beta/FIZZ2 (prepeptides mouse 105 aa; human 11 aa ~45-65% identity with FIZZ1 and 2) is highly related to resistin at the C-terminus region. Its expression is most abundant in colon (proximal and distal colon) but not in white adipose tissue. In mouse, RELM-beta is also detected at low levels in cecum and ileum. In min mouse (mouse model for human familial adenomatosus polyposis), RELM-beta expression was markedly increased in tumors immediately adjacent to normal tissue.
Molecular Weight~19kD
SourceHuman RELM-beta was expressed in E. coli
Purity98%
FormSupplied as a lyophillized powder in 10mM citrate buffer, pH 3.0. Reconstitute using 100ul PBS or Tris, pH 7.5-8.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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