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You are here:Home » Antibodies » Antibodies-Resistin » Anti -Resistin-like Molecule, gamma (RELMg, RELM-gamma)

Anti -Resistin-like Molecule, gamma (RELMg, RELM-gamma)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
RELM-gamma is a novel member of the resistin-like molecule/found in inflammatory zone (RELM/FIZZ) family in mice and rats. Microarray and real-time RT-PCR experiments revealed a repression of RELMgamma mRNA in nasal respiratory epithelium of cigarette smoke-exposed versus untreated rats. The analysis of the physiological tissue-specific expression revealed highest expression in hematopoietic tissues, suggesting a cytokine-like role for RELM-gamma. RELM-gamma-mRNA is detectable in bone marrow, spleen, and lung as well as in peripheral blood granulocytes. Promyelocytic HL60 cells transfected with a RELM-gamma expression plasmid have an increased proliferation rate compared to mock-transfected cells and display an altered response to retinoic acid-induced granulocytic differentiation. Taken together, these data provide the first experimental evidence that RELM-gamma is a secreted molecule with a restricted expression pattern that may play a role in promyelocytic differentiation.
Catalog #R1587-54
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 1:10,000-1:100,000; using 50-100 ng of control peptide/well.
Western Blot: 1:500-1:200
Optimal dilutions to be determined by the researcher.
Recommended Control PeptideR1587-55B: Resistin-like Molecule, gamma, Control Peptide
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, 0.1% sodium azide. Reconstitution: Reconstitute with 100ul sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 22aa from mouse RELM- gamma conjugated to KLH at the N-terminal. (#Q7TM98),
SpecificityRecognizes mouse RELM- gamma.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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