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You are here:Home » Molecular Biology » MB-Growth Factors-Resistin » Resistin-like Molecule, gamma, Recombinant, Mouse (RELMg)

Resistin-like Molecule, gamma, Recombinant, Mouse (RELMg)


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RELM-gamma is a novel member of the resistin-like molecule/found in inflammatory zone (RELM/FIZZ) family in mice and rats. Microarray and real-time RT-PCR experiments revealed a repression of RELMgamma mRNA in nasal respiratory epithelium of cigarette smoke-exposed versus untreated rats. The analysis of the physiological tissue-specific expression revealed highest expression in hematopoietic tissues, suggesting a cytokine-like role for RELM-gamma. RELM-gamma-mRNA is detectable in bone marrow, spleen, and lung as well as in peripheral blood granulocytes. Promyelocytic HL60 cells transfected with a RELM-gamma expression plasmid have an increased proliferation rate compared to mock-transfected cells and display an altered response to retinoic acid-induced granulocytic differentiation. Taken together, these data provide the first experimental evidence that RELM-gamma is a secreted molecule with a restricted expression pattern that may play a role in promyelocytic differentiation.
Catalog #R1587-55
DescriptionThe Recombinant Mouse RELM-gamma is a His -Tagged Fusion Protein having a molecular weight of 11kD containing 86 amino acid residues of the Mouse RELM-gamma and 16 additional amino acid residues HisTag (bold). MRGSHHHHHH GMASHMTLES IVEKKVKELL ANRDDCPSTV TKTFSCTSIT ASGRLASCPS GMTVTGCACG YGCGSWDIRD GNTCHCQCST MDWATARCCQ LA
SpecificityThe amino acid sequence of the recombinant Mouse RELM-gamma is 100% homologous to the amino acid sequence of the Mouse RELM-g.
ApplicationsWestern blotting, ELISA
SolubilityAdd 0.2 ml of 0.1M Acetate buffer pH4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10 g/ml. In higher concentrations the solubility of this antigen is limited.
StabilityStore lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. The lyophilized protein remains stable until the expiry date when stored at -20°C.
Molecular Weight11kD
SourceE. coli
Purity95% (SDS-PAGE); Two-step procedure using size exclusion chromatography before and after refolding.
FormSupplied as a lyophilized powder in 0.05M acetate buffer, pH 4.0.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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