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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -REST (Repressor Element RE-1 Silencing Transcription Factor, RE1-silencing Transcription Factor, REST Protein, Neural Restrictive Silencer Factor, Neuron Restrictive Silencer Factor, NRSF, Repressor Binding to the X2 Box, XBR)

Anti -REST (Repressor Element RE-1 Silencing Transcription Factor, RE1-silencing
Transcription Factor, REST Protein, Neural Restrictive Silencer Factor, Neuron Restrictive
Silencer Factor, NRSF, Repressor Binding to the X2 Box, XBR)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B FC
REST (NRSF/RE1) is a vertebrate silencer protein that potentially regulates a large battery of cell type-specific genes, and therefore may function as a master negative regulator of neurogenesis (1). It is a zinc finger transcription factor that during early embryogenesis is required to repress a subset of neuron-specific genes in non-neural tissues and undifferentiated neural precursors. Changes in REST splicing pattern are suggested to possibly result from altered levels of splicing factors reflecting the formation and/or progression of neuroblastoma tumors (2). REST restricts expression of a large set of genes to neurons by suppressing their expression in non-neural tissues. Its repression involves two distinct repressor proteins, CoREST and mSin3A (3). REST and CoREST together, mediate repression of the type II sodium channel promoter in nonneural cells, and the REST-CoREST complex may mediate long-term repression essential to maintenance of cell identity (4).
Catalog #R1623-01C
ApplicationsSuitable for use in Western Blot, Flow Cytometry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:2000
Flow Cytometry: 1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E524
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human REST.
SpecificityRecognizes human Rest.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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