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You are here:Home » Antibodies » Abs to Receptors, Tyrosine Kinase » Anti -Ret (Proto-oncogene Tyrosine-protein Kinase Receptor Ret, Cadherin Family Member 12, Proto-oncogene c-Ret, CDHF12)

Anti -Ret (Proto-oncogene Tyrosine-protein Kinase Receptor Ret, Cadherin Family Member 12,
Proto-oncogene c-Ret, CDHF12)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
The c-ret proto-oncogene encodes a transmembrane tyrosine kinase that contains a cadherin-like structure in the extracellular domain. Its expression was detected at high levels in the peripheral nervous systems such as the enteric and autonomic nervous systems as well as in the excretory system during embryogenesis. It is expressed preferentially in human tumors such as neuroblastoma, pheochromocytoma, and thyroid medullary carcinoma. It is considered the causative gene for human papillary thyroid carcinoma (rearrangements), multiple endocrine neoplasias types 2A and 2B (mutations), and Hirschbrung's disease. Two transcript variants encoding different isoforms have been found for this gene.
Catalog #R1636-90B
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (formalin fixed paraffin embedded): 1:10-1:20
Optimal dilutions to be determined by the researcher.
Positive ControlSmall intestine
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11E334
HostMouse
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
PuritySupernatant
ImmunogenRecombinant corresponding to the extreme C-terminal cytoplasmic region of the human ret oncoprotein. Cellular Localization: Cytoplasmic.
SpecificityRecognizes rat ret oncoprotein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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