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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -C-Ret, phosphorylated (Ser 696) (Ret Proto-oncogene, CDHF12, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51, RET-ELE1)

Anti -C-Ret, phosphorylated (Ser 696) (Ret Proto-oncogene, CDHF12, HSCR1, MEN2A, MEN2B,
MTC1, PTC, RET51, RET-ELE1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Ret is a tyrosine kinase receptor involved in the activation of several signaling pathways including the PLC gamma, Ras, JNK and inositol phosphate pathways. Ret mutations have been shown to be causative in several diseases, including Hirschsprung's disease (HD), papillary thyroid carcinoma, and multiple endocrine neoplasia (MEN) 2A, MEN 2B, and familial medullary thyroid carcinoma.
Catalog #R1637-10B
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:500
Immunohistochemistry (paraffin): 1:100
Optimal dilutions to be determined by the researcher.
Positive ControlHuvec Cell Lysate, GDNF stimulated Neuro-2A cell or TT medullary thyroid carcinoma cells
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.3, 1.0mg/mL BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide of amino acids surrounding the phosphoSerine 696 site of human c-ret. Cellular Localization: Membrane; Single-pass type I membrane protein.
SpecificityRecognizes human c-Ret phosphoSerine 696, a protein of ~170kD in lysates from Neuro-2A cells stimulated with GDNF. Species sequence homology: rat (92%), mouse (83%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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