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Anti -Retinoblastoma, phosphorylated (Thr821) (Rb)
Anti -Retinoblastoma, phosphorylated (Thr821) (Rb)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IP IC |
|
| Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1,2). Cell cycle-dependent phosphorylation by cdk’s inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4). | | | Catalog # | R1660-26H | | Applications | Suitable for use in Western Blot, Immunoprecipitation, and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Immunocytochemistry: 1:100 | | Immunoprecipitation: 1:20 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 6k347 | | Host | Rabbit | | Source | Human | | Form | Supplied as a liquid in 50mM Tris-glycine pH 7.4, 0.15M NaCl, 0.01% sodium azide, 0.05% BSA, and 40% glycerol | | Purity | Supernatant | | Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Thr821 of human Rb | | Specificity | Detects only human Rb phosphorylated on Threonine 821 | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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