Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Retinoblastoma Proteins » Anti -Retinoblastoma, phosphorylated (Thr821) (Rb)

Anti -Retinoblastoma, phosphorylated (Thr821) (Rb)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP IC
Retinoblastoma tumor suppressor protein (Rb) is associated with DNA binding activity and is thought to play a significant role in controlling cell cycle progression during tumor growth (1,2). Cell cycle-dependent phosphorylation by cdk’s inhibits Rb binding, thus allowing cell cycle progression (3). Rb inactivation and cell cycle progression likely requires first phosphorylation by cyclin D-cdk4/6 followed by cyclin E-cdk2 phosphorylation (4).
Catalog #R1660-26H
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunocytochemistry: 1:100
Immunoprecipitation: 1:20
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No6k347
HostRabbit
SourceHuman
FormSupplied as a liquid in 50mM Tris-glycine pH 7.4, 0.15M NaCl, 0.01% sodium azide, 0.05% BSA, and 40% glycerol
PuritySupernatant
ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Thr821 of human Rb
SpecificityDetects only human Rb phosphorylated on Threonine 821
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links