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Specifications

Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of epidermal growth factor (EGF). It is a G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Reveromycin A displays antiproliferative behavior against human cell lines KB and K562 as well as potent antifungal activity. More recently it has been shown to inducing apoptosis in osteoclasts thus inhibiting bone resorption.
Catalog #	R1988
Purity	>99% by HPLC
Solubility	Soluble in ethyl acetate, ethanol, methanol, DMF or DMSO. Avoid acidic conditions.
Related to	Reveromycin B, Reveromycin C, Reveromycin D
CAS Number	134615-37-5
Molecular Formula	C36H52O11
Molecular Weight	660.8
Source	Streptomyces sp.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.