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Reveromycin A


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Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of epidermal growth factor (EGF). It is a G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Reveromycin A displays antiproliferative behavior against human cell lines KB and K562 as well as potent antifungal activity. More recently it has been shown to inducing apoptosis in osteoclasts thus inhibiting bone resorption.
Catalog #R1988
Purity >99% by HPLC
Solubility Soluble in ethyl acetate, ethanol, methanol, DMF or DMSO. Avoid acidic conditions.
Related to Reveromycin B, Reveromycin C, Reveromycin D
CAS Number134615-37-5
Molecular FormulaC36H52O11
Molecular Weight660.8
SourceStreptomyces sp.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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