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Anti -RGS13 (Regulator of G Protein Signaling 13, Regulator of G-protein Signaling 13, HGNC:9995, MGC17173)
Anti -RGS13 (Regulator of G Protein Signaling 13, Regulator of G-protein Signaling 13,
HGNC:9995, MGC17173)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
B |
|
| RGS13 is the smallest member of the mammalian gene family, RGS (regulators of G protein-signaling) which are structural and functional homologues of yeast SST2 and C. elegans egl-10 proteins. RGS proteins attenuate G protein-mediated pathways by acting as GTPase-activating proteins (GAPs) for Ga subunits. RGS13 has been found most abundantly in human tonsil, thymus, lung, lymph node, and spleen. RGS13 regulate Gai, Gaq, and Gas coupled signaling cascades. It is a GTPase-activating protein for Gai and Gao. The protein blocks MAPK activity induced by Gai- or Gaq-coupled receptors. The protein also attenuates GTPase-deficient Gaq (GaqQL) mediated cAMP response element activation. The gene encoding for human RGS13 is localized on chromosome 1q31.2. | | | Catalog # | R1996-26E | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:250-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.025% sodium azide, 50% glycerol. | | Purity | Serum. | | Immunogen | Synthetic peptide corresponding to aa111-127 (RNIQEPTETCFEEAQKI) of human RGS13. | | Specificity | Recognizes human RGS13. Species sequence homology: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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