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You are here:Home » Antibodies » Abs to Serum Proteins » Anti -Rheumatoid Factor (RF)

Anti -Rheumatoid Factor (RF)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E
Rheumatoid Factors (RFs) were described as Immunoglobulins (IgGs) in rheumatoid arthritis as detected by agglutination of rabbit IgG coated erythrocytes (1). It was later demonstrated that RFs were IgM molecules reactive with the Fc-portion of the IgG from various species. In addition to the IgM RF, subsequent studies have identified RFs of other IgG subtypes (IgG, IgA, and IgE) in sera of patients with rheumatoid arthritis, and certain other chronic diseases. Most commercial assays measure predominantly IgM RFs. It has been observed that measurement of IgG RF may be a better indicator of rheumatoid arthritis than IgM RF. IgA RF and IgE RF have been implicated in articular disease process in rheumatoid arthritis and rheumatoid vasculitis, respectively. RFs, produced by cells within the joint space, are found in joint fluids as well. RF titer, particularly IgG RF correlate with the intensity of synovitis.
Catalog #R1997
RFs can be found in serum samples from a variety of autoimmune diseases including rheumatoid arthritis, Systemic lupus erythematous, Sjogren’s syndrome, mixed connective tissue disease, mixed essential cryoglobulinemia, scleroderma, subacute bacterial endocarditis, leprosy, pulmonary fibrosis, and pulmonary silicosis (1). RFs may also be found in patients with syphilis, viral infections, chronic liver diseases, sarcoidosis, leprosy, neoplasms, and a variety of other chronic conditions.
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No8.F.249
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS. No preservatives added.
PurityPurified
ImmunogenPurified human IgM cryoglobulins.
SpecificityRecognizes human Rheumatoid Factor. Recognizes 30% of IgM-RF paraproteins, does not crossreact IgM, IgA, & IgG proteins lacking RF activity.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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