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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B

The Rho proteins are members of the Ras superfamily of small GTP-binding proteins which have low molecular weight of ~21kD. Studies show that the aa sequence of the Rho family is more than 45% identical to each other and 30% or less identical to Ras or Rab/YPT proteins. The Rho proteins play an important role in the organization of actin cytoskeleton, cell adhesion, cell motility and smooth muscle contraction. The Rho proteins are also involved in the signal transduction pathways mediated by the actin cytoskeleton and the activation of the stress activated MAP kinase cascades. Researchers demostrate that Rho kinase is capable of phosphorylating purified smooth muscle myosin phosphatase and inhibiting its activity in vitro.
Catalog #	R1998-20C1
Applications	Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution	Western Blot: 1:500
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Host	Rabbit
Source	Human
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, pH 7.4, 0.02% Proclin 300.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide corresponding to aa124-146 from human Rho.
Specificity	Recognizes human Rho.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.