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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -Rho, ID

Anti -Rho, ID

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The Rho proteins are members of the Ras superfamily of small GTP-binding proteins which have low molecular weight of ~21kD. Studies show that the aa sequence of the Rho family is more than 45% identical to each other and 30% or less identical to Ras or Rab/YPT proteins. The Rho proteins play an important role in the organization of actin cytoskeleton, cell adhesion, cell motility and smooth muscle contraction. The Rho proteins are also involved in the signal transduction pathways mediated by the actin cytoskeleton and the activation of the stress activated MAP kinase cascades. Researchers demostrate that Rho kinase is capable of phosphorylating purified smooth muscle myosin phosphatase and inhibiting its activity in vitro.
Catalog #R1998-20C1
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.02% Proclin 300.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa124-146 from human Rho.
SpecificityRecognizes human Rho.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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