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You are here:Home » Antibodies » Abs to Signal Transduction » Anti -RhoGAP1 (Rho GTPase Activating Protein 1, Rho GTPase-activating Protein 1, Rho-type GTPase-activating Protein 1, RHOGAP, ARHGAP1, CDC42 GTPase-activating Protein, CDC42GAP, GTPase-activating Protein RhoOGAP, p50rhoGAP, p50-RhoGAP, Rho-related Small GTPase

Anti -RhoGAP1 (Rho GTPase Activating Protein 1, Rho GTPase-activating Protein 1, Rho-type
GTPase-activating Protein 1, RHOGAP, ARHGAP1, CDC42 GTPase-activating Protein, CDC42GAP,
GTPase-activating Protein RhoOGAP, p50rhoGAP, p50-RhoGAP, Rho-related Small GTPase

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
RhoGAP1 is a 439aa intracellular GTPase activator for the Rho proteins (Rho, Rac and Cdc42). It has a proline-rich domain, Src homology 3 (SH3) binding domain and three consensus box regions characteristic of RhoGAP. It stabilizes charges developing on the guanine nucleotide during the transition state for GTP hydrolysis and thus contributes to GAP-stimulated catalysis and converts the Rho proteins to their putatively inactive GDP-bound state with Cdc42 being the preferred substrate. Along with Rho proteins they modulate cytoskeletal changes and cell signaling. It is known to regulate the basal apoptosis of cells through the JNK pathway and also play a crucial role in regulating Rho-mediated signaling pathways. Recent reports suggest that this protein may also have a positive input to cell proliferation.
Catalog #R1998-25C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHeLa
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity Chromatography.
ImmunogenSynthetic peptide corresponding to aa1-50 of human RhoGAP1.
SpecificityRecognizes human RhoGAP1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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