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Anti -Ribonucleotide Reductase (Ribonucleoside-Diphosphate Reductase Large Subunit, Ribonucleoside-Diphosphate Reductase Subunit M1, Ribonucleotide Reductase Large Subunit, RRM1, RR1)
Anti -Ribonucleotide Reductase (Ribonucleoside-Diphosphate Reductase Large Subunit,
Ribonucleoside-Diphosphate Reductase Subunit M1, Ribonucleotide Reductase Large Subunit,
RRM1, RR1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| RRM1 is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Its gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. Its gene may play a role in malignancies and disease that involve this region. | | | Catalog # | R2031-15B | | Applications | Suitable for use in ELISA and Western Blot. Other applications have not been tested. | | Recommended Dilutions | Optimal dilutions to be determined by researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Abbit | | Source | Human | | Concentration | ~1mg/ml after reconstitution | | Form | Supplied as a lyophilized powder from PBS, pH 7.4. . To reconstitute, add 100ul ddH2O. | | Purity | Purified by Protein A affinity chromatography | | Immunogen | Synthertic peptide from the N-terminal region of RRM1 (ATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHL) | | Specificity | RRecognizes human RRM1. Species crossreactivity: mouse, rat, dog, C. elegans and zebrafish. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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