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You are here:Home » Antibodies » Abs to Protein Kinases, Ribosomal » Anti -Ribosomal Protein S6 Kinase, p70 (p70S6 Kinase, EC 2.7.11.1, p70(S6K)-alpha, p70S6K, PS6K, RPS6KB1, S6Kalpha, STK14A)

Anti -Ribosomal Protein S6 Kinase, p70 (p70S6 Kinase, EC 2.7.11.1, p70(S6K)-alpha, p70S6K,
PS6K, RPS6KB1, S6Kalpha, STK14A)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The protein p70 S6 kinase is critical for cell cycle progression and cell survival. In response to mitogen stimulation, p70 S6 kinase activation up- regulates ribosomal biosynthesis and enhances the translational capacity. The p70S6K phosphorylates the S6 protein of the 40S subunit of the ribosome. This kinase was first characterized as an insulin/mitogen- activated protein kinase, whose major known substrate is the 40 S ribosomal subunit protein S6. The p70 S6 kinase is activated by diverse stimuli through a multi-site phosphorylation such as Thr-252 and Ser- 434. In Alzheimer's disease (AD), p70 S6 kinase activation is associated with PHF-tau (hyperphosphorylated tau) accumulation. In non-neuronal cells, p70 S6 kinase have been shown to regulate actin polymerization.
Catalog #R2031-38C1
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human p70S6K surrounding Serine 434 (VAPSVLE).
SpecificityRecognizes human p70S6K. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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