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You are here:Home » Antibodies » Abs to Protein Kinases, Ribosomal » Anti -RPS6KB1 (Ribosomal Protein S6 Kinase beta-1, S6K-beta-1, S6K1, 70kD Ribosomal Protein S6 Kinase 1, P70S6K1, p70-S6K 1, p70 Ribosomal S6 Kinase alpha, p70 S6 Kinase alpha, p70 S6K-alpha, p70 S6KA, p70-S6K, Ribosomal Protein S6 Kinase I, Serine/threonine-pr

Anti -RPS6KB1 (Ribosomal Protein S6 Kinase beta-1, S6K-beta-1, S6K1, 70kD Ribosomal
Protein S6 Kinase 1, P70S6K1, p70-S6K 1, p70 Ribosomal S6 Kinase alpha, p70 S6 Kinase
alpha, p70 S6K-alpha, p70 S6KA, p70-S6K, Ribosomal Protein S6 Kinase I,
Serine/threonine-pr

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Serum E B
The 70kD ribosomal S6 kinase, p70S6K1, is a serine/threonine kinase that functions as a downstream target of the phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen-activated protein (MAP) kinase signaling pathways. p70S6K1 mediates several effects of the PI3K/AKT pathway, including cellular transformation. The protein is also involved in neuronal cell differentiation, cell cycle progression and promotes the G1 phase of the cell cycle in response to growth factors. The protein has been implicated in inducing actin filament remodeling, an essential process for cell migration. Recent data suggests that the protein regulates the expression of an oncoprotein, HDM2, thus mediating tumor growth. Human p70S6K1 gene is localized in the chromosomal region 17q23.1. The protein is widely expressed and exists in two isoforms: a 70kD cytoplasmic form and a 85kD nuclear form.
Catalog #R2031-38U4
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa512-525 (ISKRPEHLRMNL) of human p70S6K1.
SpecificityRecognizes human p70S6K1. Species Crossreactivity: bovine, mouse, rabbit, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesRibosomal Protein S6 Kinase 70kDa Polypeptide 1, EC=2.7.11.1, p70-alpha, p70(S6K)-alpha, PS6K, S6K1


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