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You are here:Home » Antibodies » Abs to Signal Transduction » Anti -Rictor (Rapamycin Insensitive Companion of mTOR, Rapamycin-insensitive Companion of mTOR, RICTR, AVO3 Homolog, hAVO3, KIAA1999, mAVO3, PIA)

Anti -Rictor (Rapamycin Insensitive Companion of mTOR, Rapamycin-insensitive Companion of
mTOR, RICTR, AVO3 Homolog, hAVO3, KIAA1999, mAVO3, PIA)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Purified IP
Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GBL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GBL, Sin1 and rictor (1). The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro (2). This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes (3). This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR (4).
Catalog #R2031-62N
ApplicationsSuitable for use in Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No11C1092
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol.
PurityPurified
ImmunogenSynthetic peptide corresponding to the sequence around Leu1121 of human rictor.
SpecificityRecognizes Rictor (Sepharose Bead Conjugate). Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesRPTOR Independent Companion of MTOR, Complex 2, DKFZp686B11164, MGC39830, Pianissimo


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