Anti -Rictor (Rapamycin Insensitive Companion of mTOR, Rapamycin-insensitive Companion of
mTOR, RICTR, AVO3 Homolog, hAVO3, KIAA1999, mAVO3, PIA)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Purified |
IP |
|
| Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GBL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GBL, Sin1 and rictor (1). The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro (2). This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes (3). This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR (4). | | | Catalog # | R2031-62N | | Applications | Suitable for use in Immunoprecipitation. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 11C1092 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 10mM sodium HEPES, pH7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol. | | Purity | Purified | | Immunogen | Synthetic peptide corresponding to the sequence around Leu1121 of human rictor. | | Specificity | Recognizes Rictor (Sepharose Bead Conjugate). Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | RPTOR Independent Companion of MTOR, Complex 2, DKFZp686B11164, MGC39830, Pianissimo |
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