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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -Ring Finger Protein 31 (RNF31, FLJ10111, FLJ23501, HOIL-1-interacting Protein, HOIP, MGC19975, Zinc in-between-RING-finger Ubiquitin-associated Domain Protein, ZIBRA)

Anti -Ring Finger Protein 31 (RNF31, FLJ10111, FLJ23501, HOIL-1-interacting Protein, HOIP,
MGC19975, Zinc in-between-RING-finger Ubiquitin-associated Domain Protein, ZIBRA)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.
Catalog #R2031-86L
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 1-3ug/ml, lysates of cell line HepG2 observed on ~120kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-EEVPLGQSIPRRRK, from human RNF31, at C-terminal (AAH12077.1).
SpecificityRecognizes human RNF31. Species sequence homology: Canine and porcine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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