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You are here:Home » Antibodies » Abs to Enzymes, Polymerase » Anti -RNA Polymerase II (MGC75453, B220, DNA-directed RNA Polymerase II Largest Subunit, hRPB220, hsRPB1, POLR2, POLR2A, POLRA, RNA Polymerase II (DNA directed) Polypeptide A 220kD, RPB1, RPB220, RPBh1, RpIILS, RPO2, RPOL2)

Anti -RNA Polymerase II (MGC75453, B220, DNA-directed RNA Polymerase II Largest Subunit,
hRPB220, hsRPB1, POLR2, POLR2A, POLRA, RNA Polymerase II (DNA directed) Polypeptide A
220kD, RPB1, RPB220, RPBh1, RpIILS, RPO2, RPOL2)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites
The carboxy-terminal repeat domain (CTD) of the largest subunit of RNA Pol II contains tandem repeats of a heptapeptide sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser which is highly conserved among eukaryotic organisms. There are two forms of RNA Pol II in vivo, designated IIO, which is extensively phosphorylated at the CTD, and IIA, which is not phosphorylated. The IIA
form preferentially enters the pre-initiation complex (PIC), whereas IIO is found in the elongating complex. The kinase activity of TFIIH can mediate CTD phosphorylation, although other kinases, including Cdc2, Ctk1, the Srb10-Srb11 kinase-cyclin pair, and P-TEF , have also been implicated in CTD phosphorylation. A phosphatase responsible for the dephosphorylation of the CTD has also been identified. CTD phosphatase activity is regulated by TFIIB and TFIIF. The CTD has also been implicated in pre-mRNA processing, most likely functioning as a platform for the
recruitment and assembly of factors involved in pre-mRNA processing. -RNA Pol II (CTD) is a mouse monoclonal antibody (ascites) without further purification.
Catalog #R2039-20A
Clone TypeMonoclonal
IsotypeIgG-a2
Clone No6D747
HostMouse
FormLiquid. Supplied as ascites.
PurityAscites
Specificity-RNA Pol II (CTD) reacts with the CTD subunit in HeLa nuclear extract by Western
blotting. Recommended dilution range for Western blot analysis1
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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