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You are here:Home » Antibodies » Abs to Cullin » Anti -Ring Finger Protein 7 (RNF7, CKII beta-binding Protein 1, CKBBP1, Regulator of Cullins 2, ROC2, RING Box Protein 2, Rbx2, Sensitive to Apoptosis Gene, Sensitive to Apoptosis Gene Protein, SAG, Zinc RING Finger Protein SAG)

Anti -Ring Finger Protein 7 (RNF7, CKII beta-binding Protein 1, CKBBP1, Regulator of
Cullins 2, ROC2, RING Box Protein 2, Rbx2, Sensitive to Apoptosis Gene, Sensitive to
Apoptosis Gene Protein, SAG, Zinc RING Finger Protein SAG)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Catalog #R2993-81K
ApplicationsSuitable for use in ELISA and Western Blot. Other applications have not been tested.
Recommended Dilutions
Peptide ELISA Titer: 1:8000
Western Blot: 1-3ug/ml ~11kD band observed in Human Human Heart lysates (calculated MW of 12.7kD according to NP_055060.1).
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by peptide affinity chromatography.
ImmunogenSynthetic peptide corresponding to DACLRCQAENKQE, from the internal region of human RNF7 (NP_055060.1).
SpecificityRecognizes human RNF7. Species sequence homology: mouse. This antibody is expected to recognize isoform 1 (NP_055060.1).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate nameszinc RING finger protein SAG, sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2, regulator of cullins 2, OTTHUMP00000180645, SAG, ROC2, CKBBP1, ring finger protein 7, RNF7


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