Anti -Ring Finger Protein 7 (RNF7, CKII beta-binding Protein 1, CKBBP1, Regulator of
Cullins 2, ROC2, RING Box Protein 2, Rbx2, Sensitive to Apoptosis Gene, Sensitive to
Apoptosis Gene Protein, SAG, Zinc RING Finger Protein SAG)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
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| The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. | | | Catalog # | R2993-81K | | Applications | Suitable for use in ELISA and Western Blot. Other applications have not been tested. | | Recommended Dilutions | | | Peptide ELISA Titer: 1:8000 | | Western Blot: 1-3ug/ml ~11kD band observed in Human Human Heart lysates (calculated MW of 12.7kD according to NP_055060.1). | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. | | Purity | Purified by peptide affinity chromatography. | | Immunogen | Synthetic peptide corresponding to DACLRCQAENKQE, from the internal region of human RNF7 (NP_055060.1). | | Specificity | Recognizes human RNF7. Species sequence homology: mouse. This antibody is expected to recognize isoform 1 (NP_055060.1). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | zinc RING finger protein SAG, sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2, regulator of cullins 2, OTTHUMP00000180645, SAG, ROC2, CKBBP1, ring finger protein 7, RNF7 |
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Download Specifications for Anti -Ring Finger Protein 7 (RNF7, CKII beta-binding Protein 1, CKBBP1, Regulator of Cullins 2, ROC2, RING Box Protein 2, Rbx2, Sensitive to Apoptosis Gene, Sensitive to Apoptosis Gene Protein, SAG, Zinc RING Finger Protein SAG) |
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