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You are here:Home » Antibodies » Abs to Infectious Disease Rotavirus » Anti -Rotavirus, ICP, Late Structural Virion Antigens

Anti -Rotavirus, ICP, Late Structural Virion Antigens

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Specifications

Clone Host Grade Applications
Polyclonal Goat Highly Purified E IC IF
Rotaviruses, members of the family Reoviridae, are a major cause of diarrhea in young mammals. Human rotaviruses, the major etiological agents of severe infantile diarrhea worldwide, display very diverse and complex serotypic specificities. Rotaviruses are 70nm, non enveloped viruses comprised of a triple layered protein capsid; Outer capsid proteins are VP4 and VP7, Inner capsid -VP6 and Core -VP2. The immunity acquired from exposure to rotavirus appears to be type specific following initial infection. Therefore, multiple serotypes of rotavirus mean multiple opportunities for infection. The combination of animal reservoirs for the virus and rotavirus gene reassortment provides the potential for dramatic genetic shifts (similar to influenza virus) which could give rise to altered host ranges and viral virulence.
Catalog #R3000-01D
ApplicationsSuitable for use in ELISA, Immunofluorescence and Immunocytochemistry. It is also suitable for Conjugation purposes. Other applications not tested.
Recommended DilutionIndirect Immunofluorescence: ~1:250 Acetone fixation
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
Concentration~4-5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. No stabilizing proteins have been added.
PurityPurified IgG fraction to a purity of > 95%.
ImmunogenBovine (Nebraska Calf Diarrhea Virus).
SpecificityRecognizes ICPs and late structural (virion) antigens. > 90% with human rotaviruses (reported). Uninfected Cell Reactivity: Negative vs. HEp-2 cells and WI-38 cells by indirect immunofluorescence.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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