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You are here:Home » Antibodies » Abs to Enzymes, Polymerase » Anti -S6K1 Aly/REF-like Target alpha, beta (SKAR, 46kD DNA Polymerase delta Interaction Protein, p46, PDIP46, KIAA1649, Polymerase delta-interacting Protein 3, POLDIP3)

Anti -S6K1 Aly/REF-like Target alpha, beta (SKAR, 46kD DNA Polymerase delta Interaction
Protein, p46, PDIP46, KIAA1649, Polymerase delta-interacting Protein 3, POLDIP3)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Purified B IF
p70 S6 kinase is a mitogen activated Ser/Thr protein kinase downstream of phosphoinositide-3 kinase (PI3K) and the target of rapamycin, FRAP/mTOR. p70 S6 kinase is required for cell growth and cell cycle progression (1,2). SKAR is a recently discovered substrate of S6K1. SKAR exists in two isoforms, a and b, the latter having a 29aa truncation. Phosphorylation of SKAR is mitogen-induced and sensitive to rapamycin. Reduction in SKAR protein levels results in decreased cell size, further implicating SKAR in cell growth control (3).
Catalog #S0050-85
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionImmunofluorescence (IF-IC): 1:3200
Western Blot: 1:1000 Icubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No11C1067
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, less than 0.02% sodium azide, 50% glycerol.
PurityPurified
ImmunogenSynthetic peptide corresponding to the amino terminus of human SKAR.
SpecificityRecognizes endogenous levels of total SKAR protein, A/B isoforms. Species Crossreactivity: monkey, mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPolymerase (DNA-directed), delta Interacting Protein 3


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