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You are here:Home » Antibodies » Abs to PDZ Domain » Anti -SAP102 (Synapse-associated Protein 102, bA291O7.3, Discs Large Drosophila Homolog 3, Discs Large Homolog 3, DLG3, KIAA1232, mKIAA1232, MRX, MRX90, Neuroendocrine dlg, NEDLG, NE-Dlg, XLMR)

Anti -SAP102 (Synapse-associated Protein 102, bA291O7.3, Discs Large Drosophila Homolog 3,
Discs Large Homolog 3, DLG3, KIAA1232, mKIAA1232, MRX, MRX90, Neuroendocrine dlg, NEDLG,
NE-Dlg, XLMR)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of the family, SAP102 has three ~90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity.
SAP102 is believed to participate in the clustering of certain proteins, including NMDA receptors, shaker-type potassium channels at the synaptic membrane in CNS neurons. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP102 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP102 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
Catalog #S0093-05B
ApplicationsSuitable for use in Western Blot and Immunohistochemistry (Fr). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Cellular Localization Synaptic membrane.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationAs reported
FormPBS with 1 mg/ml BSA containing 0.05% sodium azide
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: G(83)PVPPKPVPGKNTPKLNG(100).Immunizing peptide corresponds to amino acid residues 83-100 of rat SAP 102.
SpecificitySpecies Crossreactivity: Crossreacts with Rat. Does not crossreact with Mouse (see review).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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