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You are here:Home » Antibodies » Abs to PDZ Domain » Anti -SAP102 (Synapse-associated Protein 102, bA291O7.3, Discs Large Drosophila Homolog 3, Discs Large Homolog 3, DLG3, KIAA1232, mKIAA1232, MRX, MRX90, Neuroendocrine dlg, NEDLG, NE-Dlg, XLMR)

Anti -SAP102 (Synapse-associated Protein 102, bA291O7.3, Discs Large Drosophila Homolog 3,
Discs Large Homolog 3, DLG3, KIAA1232, mKIAA1232, MRX, MRX90, Neuroendocrine dlg, NEDLG,
NE-Dlg, XLMR)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein
family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal (1, 2). SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homolgy 3 domain and a guanylate kinase domain (3). All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with
the carboxy-terminal domain of the N-methyl-D- aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway (3, 4). SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains (3). In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
Catalog #S0093-05C
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10F763
HostMouse
SourceRat
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide and 50% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenFusion protein aa 1-120 of rat SAP102 (accession number Q62936).
SpecificityRecognizes rat sap102. Species Crossreactivity: human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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