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You are here:Home » Antibodies » Abs to Splicing Factors » Anti -SAP130 (Spliceosome-associated Protein 130, SAP 130, KIAA0017, Pre-mRNA-splicing Factor SF3b 130kD Subunit, RSE1, Splicing Factor 3B Subunit 3, SF3B3, SF3b130, STAF130)

Anti -SAP130 (Spliceosome-associated Protein 130, SAP 130, KIAA0017, Pre-mRNA-splicing
Factor SF3b 130kD Subunit, RSE1, Splicing Factor 3B Subunit 3, SF3B3, SF3b130, STAF130)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
Catalog #S0093-35B
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-0.3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlNuclear lysate from HeLa cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-VSKKLEDIRTRYAF, from the C-terminus of the protein sequence according to NP_036558.3.
SpecificityRecognizes human SAP130/SF3B3. Species sequence homology: mouse, rat, canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesSplicing Factor 3b, Subunit 3, 130kDa


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