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SAPK2, p38 MAPK Inhibitor (SB 202190) (Stress-activated Protein Kinase 2)
SAPK2, p38 MAPK Inhibitor (SB 202190) (Stress-activated Protein Kinase 2)
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| SB 202190 is a cell permeable pyridinyl imidazole, which acts as a strong inhibitor of SAPK2a/p38 and SAPK2b/p38beta MAP kinases (IC50=280nM and 350nM, respectively). SB 202190 has no effect on the activity of the Erk or SAPK/JNK MAP kinases and is reported to block LPS induced TNF-a and IL-1beta production in mice. The compound is a slightly better inhibitor than the related compound SB 203580. | | | Catalog # | S0096-25 | | Solubility | Soluble in DMSO (50mg/ml). | | Applications | Specific inhibitor of p38/SAPK2a MAPK and P38b/SAPK2a MAPK activity. Other applications not tested. | | Protein Kinase Inhibition Assay | When pre-incubated for five minutes with 0.2ug of SAPK2a/p38 MAPK or SAPK2b/p38beta MAPK, 1-10uM of SB 202190 will inhibit the activity of these kinases 80-95%. The final concentration of SB 202190 needed may depend on the amount of enzyme used. Optimal dilutions to be determined by the researcher. | | Storage and Stability | Stable for at least 12 months at -20°C in the dark. After reconstitution, aliquot and freeze at -20°C, away from light. | | CAS Number | 152121-30-7 | | Molecular Formula | C20H14FN3O | | Molecular Weight | 331.3 | | Purity | 98% (HPLC) | | Form | Supplied as a pale yellow solid. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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