Anti -SARM (SAM and ARM-containing Protein, FLJ36296, KIAA0524, Ortholog of Sterile alpha
and HEAT/Armadillo Motif Protein, SAMD2, Sterile alpha and Armadillo Repeat Protein,
Sterile alpha and TIR Motif Containing 1, Sterile alpha and TIR Motif-containing Prote
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
B |
|
| Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-kappaB, and ultimately the expression of proteins involved in host defense (4,5). While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule (4,5). | | | | | | Applications: | | | Suitable for use in Western Blot. Other applications not tested. | | | Catalog # | S0097-70E | | Recommended Dilution | Western Blot: 0.5-2 ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As Reported | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified. | | Immunogen | Synthetic peptide corresponding to amino acids near the C-terminus of human SARM (NP_055892). | | Specificity | Recognizes human SARM. Species Cross Reactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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