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You are here:Home » Antibodies » Abs to Transcription Factors, Homeobox (HOX) » Anti -SATB Family Member 2 (Special AT-rich Sequence-Binding Protein 2, SATB Homeobox 2, SATB2, FLJ21474, FLJ32076, KIAA1034, MGC119474, MGC119477)

Anti -SATB Family Member 2 (Special AT-rich Sequence-Binding Protein 2, SATB Homeobox 2,
SATB2, FLJ21474, FLJ32076, KIAA1034, MGC119474, MGC119477)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH
Special AT-rich sequence-binding protein 2 (SATB2) is a DNA-binding protein of the CUT homeobox family that regulates chromatin organization and gene expression (1). It functions as a transcription factor that controls nuclear gene expression. SATB2 binds to matrix attachment regions (MARs) of DNA, inducing local chromatin-loop remodeling (2). This protein acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers (2). Furthermore, it acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation (3). It is highly expressed in the adult brain, with moderate expression in the fetal brain (2). In developing brains, SATB2 is expressed in cortical neurons that extend axons across the corpus callosum (1). Defects in SATB2 are the cause of isolated cleft palate with mental retardation (1).
Catalog #S0098-86A
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-10,000
Immunohistochemistry: 1: 100-250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No10g120
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid in 50mM Tris-Glycine pH 7.4, 0.15M NaCl, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in human SATB2.
SpecificityRecognizes human SATB2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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