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You are here:Home » Antibodies » Abs to Receptors, Scavenger » Anti -Scavenger Receptor BI (SR-BI)

Anti -Scavenger Receptor BI (SR-BI)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH FC
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
Catalog #S0099-01
ApplicationsSuitable for use in Immunofluorescence, Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionFACS: 1:100
Western Blot: 1:1000-1:5000
Immunohistochemistry (Paraffin): 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenA peptide containing residues 496-509 from mouse Scavenger Receptor-BI plus an N-terminal cysteine was coupled to KLH. CSPAAKGTVLQEAKL-COOH.
SpecificityRecognizes mouse SR-BI. Species crossreactivity: rat , mink and hamster SR-BI and the long form of human CLA-I.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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