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You are here:Home » Antibodies » Abs to Receptors, Scavenger » Anti -Scavenger Receptor BI (Scavenger Receptor Class B Member 1, Scavenger Receptor Class B Type 1, Scavenging Receptor SR-BI, SCARB1, SRB1, SRBI, SR-BI, CD36 and LIMPII Analogous 1, CD36 Antigen-like 1, CD36L1, CLA1, CLA-1, Collagen Type I Receptor, MGC138242

Anti -Scavenger Receptor BI (Scavenger Receptor Class B Member 1, Scavenger Receptor Class
B Type 1, Scavenging Receptor SR-BI, SCARB1, SRB1, SRBI, SR-BI, CD36 and LIMPII Analogous
1, CD36 Antigen-like 1, CD36L1, CLA1, CLA-1, Collagen Type I Receptor, MGC138242

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH FC N
Monoclonal antibody 3D12 reacts with rat class B scavenger receptor type I (SR-BI). Scavenger receptors have been studied primarily for their ability to bind and internalize modified lipoproteins. They have been found in the development of atherosclerosis and other macrophage-associated functions. Scavenger receptors also function as pattern recognition receptors for a wide variety of pathogens. This finding indicates a potential role in host defense.
SR-BI belongs together with CD36 to the class B scavenger receptor family. SR-BI is a multiligand membrane protein existing in various organs such as the liver and various cell types such as endothelial cells, macrophages, brain cells, Leydig cells and Sertoli cells. SR-BI has been found as a receptor for phospholipids, free and (lipo)protein-bound ApoE, lipid-bound ApoA-I, HDL, hypochlorite-modified LDL and more.
Catalog #S0099-01F
In liver, the PDZK-1 (and possible other PDZ domains) of SR-BI has been found to be essential for cell surface expression and, hence, reverse cholesterol transport. In the brain, the presence of SR-BI seems to be involved in the uptake of oxidatively modified lipoproteins and beta-amyloid protein complexed with ApoE, suggesting SR-BI to be an important tool for studies on neurodegenerative disorders. In the testis, SR-BI is expressed in two somatic cell types Leydig cells and Sertoli cells. SR-BI functions at least partly as a phosphatidyl serine receptor (PSR), enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation.
ApplicationsSuitable for use in Flow Cytometry, Immunohistochemistry, and Neutralization of the biological activity of SR-BI. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:50
Immunohistochemistry (frozen): 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9G265
HostMouse
SourceRat
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.1% BSA.
PurityPurified
Immunogen144-163 aa peptide with cys at amino terminus.
SpecificityRecognizes rat class B scavenger receptor type I (SR-BI). Blocks the biological activity of rat SR-BI. For example, it inhibits the ability of SR-BI to mediate the corporation of lipids of HDL by SR-BI expressing cells.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesSR-BI


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