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You are here:Home » Antibodies » Abs to Receptors, Scavenger » Anti -Scavenger Receptor BI/BII (Scavenger Receptor-B1/B2, SR-BI/BII, SR-B1/B2, Scavenger Receptor Class B Type I, SCARB1, SRBI, Scavenger Receptor Class B Member 2, SRBII, SCARB2, 85kD Lysosomal Membrane Sialoglycoprotein, CD36 and LIMPII Analogous 1, CLA1, CD

Anti -Scavenger Receptor BI/BII (Scavenger Receptor-B1/B2, SR-BI/BII, SR-B1/B2, Scavenger
Receptor Class B Type I, SCARB1, SRBI, Scavenger Receptor Class B Member 2, SRBII, SCARB2,
85kD Lysosomal Membrane Sialoglycoprotein, CD36 and LIMPII Analogous 1, CLA1, CD

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP IH IC FC IF
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
Catalog #S0099-02C
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Immunohistochemistry, Immunoprecipitation and Immunoflourescence/Immunocytochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:400
Western Blot: 1:1000 detects a band of ~82kD in tissues that express SR-BI and/or SR-BII such as liver, ovary, adrenal glands and to as lesser extent testes, heart and mammary glands.
Immunohistochemistry: 1:10-1:2000
Immunofluorescence/Immunocytochemistry: 1:50-1:1000 Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
ConcentrationNot determined
FormSupplied as a liquid, 0.02% sodium azide.
PuritySerum
ImmunogenPeptide from the extracellular domain (aa230-380) of Scavenger Receptor-BI/BII expressed as two tandem copies in bacteria. Cellular Localization: Lysosome, lysosomal membrane, multi-pass membrane protein.
SpecificityRecognizes Scavenger Receptors BI and Scavenger Receptors BII at ~82kD. Species Crossreactivity: mouse, human, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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