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Anti -SCAMP3 (secretory carrier membrane protein 3, "Propin 1", C1orf3, PROPIN1, Secretory carrier-associated membrane protein 3, Secretory carrier membrane protein 3)
Anti -SCAMP3 (secretory carrier membrane protein 3, "Propin 1", C1orf3, PROPIN1, Secretory
carrier-associated membrane protein 3, Secretory carrier membrane protein 3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Sheep |
Affinity Purified |
B |
|
| SCAMP3 (Secretory carrier membrane protein 3) is a 38-40kD member of the SCAMP | | | family of proteins. It is expressed in heart and skeletal muscle, plus fat, and functions in | | | post-Golgi recycling and EGFR internalization pathways. Human SCAMP3 is 347aa in length. It contains a cytoplasmic N-terminus (aa1-170) that shows three NPF repeats (binding sites for EH domain proteins), a heptad repeat of aliphatic aa’s, and a potential SH3-binding motif. This is followed by four consecutive transmembrane domains (aa171-297) plus a C-terminal cytoplasmic region (aa298-347). It appears that phosphorylation of SCAMP3 on Tyr41 is a requisite for its interaction with EGFR. There are three potential splice forms. One shows a deletion of aa 23-48, while two others show a one and 23 aa substitution for aa131-144 and 131-260, respectively. Over aa1-170, human and mouse SCAMP3 are 91% aa identical. | | | Catalog # | S0442-01C | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1.0ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Sheep | | Source | Human | | Concentration | As reported | | Form | Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant human SCAMP3, aa1- 170; O14828 (E. coli). | | Specificity | Recognizes human/mouse SCAMP3. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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