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Anti -Secretory Component Glycoprotein (Secretory Component p85, Extracellular matrix protein 1, ECM1, ECM-1, Epithelial Transport Receptor)
Anti -Secretory Component Glycoprotein (Secretory Component p85, Extracellular matrix
protein 1, ECM1, ECM-1, Epithelial Transport Receptor)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IH |
|
| Secretory Component Glycoprotein is an epithelial transport receptor for polymeric IgA and IgM. Antibody to secretory component has been shown to be useful for identifying glandular carcinomas. Defects in Secretory Component Glycoprotein are the cause of lipoid proteinosis (LiP), also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane. | | | Catalog # | S0630-05A | | Applications | Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Western Blot: 1:1000 | | Immunoprecipitation: 1:50 | | Immunohistochemistry (Frozen, paraffin): 1:200 | | Optimal dilutions to be determined by the researcher. | | Positive Controls | Secretory mucosa of gastrointestinal and respiratory tract, Epithelia of salivary glands, Endometrium, Endocervix, Kidney, Prostate, Mammary gland | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9E678 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide. | | Purity | Purified by affinity chromatography. | | Immunogen | Full length native protein (affinity-purified secretory component) (Human colostrum) | | Specificity | Recognizes 80kD human secretory component glycoprotein (both free and bound in secretory IgA). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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