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Anti -Secretory Component Glycoprotein (Secretory Component p85, Extracellular Matrix Protein 1, ECM1, ECM-1, HGNC:3153)
Anti -Secretory Component Glycoprotein (Secretory Component p85, Extracellular Matrix
Protein 1, ECM1, ECM-1, HGNC:3153)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IH |
|
| Secretory Component Glycoprotein is an epithelial transport receptor for polymeric IgA and IgM. Antibody to secretory component has been shown to be useful for identifying glandular carcinomas. Defects in Secretory Component Glycoprotein are the cause of lipoid proteinosis (LiP), also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane. | | | Catalog # | S0630-05B | | Applications | Suitable for use in Immunohistochemistry, Western Blot and Immunoprecipitation. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry: Frozen and paraffin sections | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | SC-05 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in TBS, pH 8.0, 15mM sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Secretory Component from human colostrum. | | Specificity | Recognizes the human 80kD Secretory Component Glycoprotein (both free and bound in secretory IgA). Recognized glycoprotein is a specific membrane marker of glandular carcinomas. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Epithelial Transport Receptor |
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