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You are here:Home » Antibodies » Abs to Extracellular Matrix Proteins » Anti -Secretory Component Glycoprotein (Secretory Component p85, Extracellular Matrix Protein 1, ECM1, ECM-1, HGNC:3153)

Anti -Secretory Component Glycoprotein (Secretory Component p85, Extracellular Matrix
Protein 1, ECM1, ECM-1, HGNC:3153)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
Secretory Component Glycoprotein is an epithelial transport receptor for polymeric IgA and IgM. Antibody to secretory component has been shown to be useful for identifying glandular carcinomas. Defects in Secretory Component Glycoprotein are the cause of lipoid proteinosis (LiP), also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
Catalog #S0630-05B
ApplicationsSuitable for use in Immunohistochemistry, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Frozen and paraffin sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone NoSC-05
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in TBS, pH 8.0, 15mM sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSecretory Component from human colostrum.
SpecificityRecognizes the human 80kD Secretory Component Glycoprotein (both free and bound in secretory IgA). Recognized glycoprotein is a specific membrane marker of glandular carcinomas.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEpithelial Transport Receptor


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