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Anti -Secretory Leukocyte Protease Inhibitor (SLPI)
Anti -Secretory Leukocyte Protease Inhibitor (SLPI)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B IH N |
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| Human Secretory Leukocyte Protease Inhibitor SLPI is a protein found in various secretory fluids, including parotid secretions, bronchial, nasal and cervical mucus, and seminal fluid. The protein is a potent inhibitor of a variety of proteolytic enzymes, including the neutrophil proteases, elastase and cathepsin G and the pancreatic proteases chymotrypsin and trypsin. SLPI is an important component of the antiprotease defense of tissues bathed by secretory fluids and could be useful as a therapeutic agent for treatment of the proteolytic damage of tissues seen in degenerative and inflammatory diseases. | | | Catalog # | S0635 | | Applications | Suitable for use in Neutralization, Direct ELISA, Immunohistochemistry and Western Blot. Other applications not tested. | | Recommended Dilution | Neutralization: ~1.5ug/ml (ND50) Neutralizes 50% of the activity at 0.125ug/ml of S0635-01B Secretory Leukocyte Protease Inhibitor Recombinant Human inhibition of 0..5ug/ml of Trypsin cleavage of the fluorogenic peptide substrate McaRPKPVENvalWRK(Dnp)NH2 (10uM). The | | Western Blot: 0.1ug/ml (S0635-01B) | | Immunohistochemistry: 5-15ug/ml Immersion fixed paraffinembedded sections of human skin. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.2mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant corresponding to a26-132 of human SLPI expressed in E. coli (P03973). | | Specificity | Recognizes human SLPI in direct ELISA and Western Blot. ~20% crossreactivity with mouse SLPI (ELISA). Antibody neutralizes SLPI biological activity. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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