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You are here:Home » Molecular Biology » MB-Protease Inhibitors » Secretory Leukocyte Protease Inhibitor Recombinant Human (SLPI, ALK1, ALP, BLPI, HUSI, HUSI-I, WAP4, WFDC4 Four-disulfide core domain 4, Antileukoproteinase, Mucus proteinase inhibitor, Seminal proteinase inhibitor)

Secretory Leukocyte Protease Inhibitor Recombinant Human (SLPI, ALK1, ALP, BLPI, HUSI,
HUSI-I, WAP4, WFDC4 Four-disulfide core domain 4, Antileukoproteinase, Mucus proteinase
inhibitor, Seminal proteinase inhibitor)

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Specifications

Human Secretory Leukocyte Protease Inhibitor SLPI is a protein found in various secretory fluids, including parotid secretions, bronchial, nasal and cervical mucus, and seminal fluid. The protein is a potent inhibitor of a variety of proteolytic enzymes, including the neutrophil proteases, elastase and cathepsin G and the pancreatic proteases chymotrypsin and trypsin. SLPI is an important component of the antiprotease defense of tissues bathed by secretory fluids and could be useful as a therapeutic agent for treatment of the proteolytic damage of tissues seen in degenerative and inflammatory diseases.
Catalog #S0635-01B
SourceRecombinant corresponding to aa26-132 of human SLPI expressed in E. coli (P03973).
Predicted Molecular Weight~12kD.
ActivityMeasured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca­RPKPVE­Nval­WRK(Dnp)­NH2. The IC50 value is 4.0nM, under the described conditions. See Activity Assay Protocol.
Storage and StabilityLyophilized powder is stable for up to 12 months from date of receipt at -20°C. Reconstituted product is stable for 6 months at -20°C to -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity97% (SDS-PAGE under reducing conditions, silver stain). Endotoxin: 1.0 EU/ug (LAL).
ConcentrationNot determined.
FormSupplied as a lyophilized powder from a sterile-filtered PBS, pH 7.4. Reconstitute with 200ul PBS.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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