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You are here:Home » Antibodies » Abs to Protease Inhibitors » Anti -Secretory Leukocyte Protease Inhibitor (SLPI, ALK1, Antileukoproteinase, ALP, BLPI, HUSI, HUSI-1, HUSI-I, Mucus Proteinase Inhibitor, MPI, Protease Inhibitor WAP4, Secretory Leukocyte Peptidase Inhibitor, Seminal Proteinase Inhibitor, WAP4, WAP Four-Disul

Anti -Secretory Leukocyte Protease Inhibitor (SLPI, ALK1, Antileukoproteinase, ALP, BLPI,
HUSI, HUSI-1, HUSI-I, Mucus Proteinase Inhibitor, MPI, Protease Inhibitor WAP4, Secretory
Leukocyte Peptidase Inhibitor, Seminal Proteinase Inhibitor, WAP4, WAP Four-Disul

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
SLPI, also known as antileukoprotease (ALP), is a 11.7kD cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs, by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulphide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).
Catalog #S0635-01C
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:10
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman secretory leukocyte proteinase inhibitor (SLPI).
SpecificityRecognizes human secretory leukocyte proteinase inhibitor (SLPI).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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