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You are here:Home » Antibodies » Abs to Protease Inhibitors » Anti -Secretory Leukocyte Protease Inhibitor (SLPI)

Anti -Secretory Leukocyte Protease Inhibitor (SLPI)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
SLPI is a 11.7kD cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs, by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulfide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).
Catalog #S0635-02
ApplicationsUseful for Western Blot, immunoassays and Immunoprecipitation.
Recommended DilutionWestern Blot: 1:10
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, containing 0.02% sodium azide and 0.1% BSA.
PurityPurified IgG
SpecificityReacts with secretory leukocyte proteinase inhibitor (SLPI; also known as antileukoprotease or ALP).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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