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Anti -Secretory Leukocyte Protease Inhibitor (SLPI)
Anti -Secretory Leukocyte Protease Inhibitor (SLPI)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IP IH |
|
| SLPI is a 11.7kD cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs and by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulfide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV). | | | Catalog # | S0635-03 | | Applications | Suitable for use in Immunohistochemistry, Western Blot, Immunoprecipitation and ELISA. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Frozen/paraffin): 1:50 (5ug/ml) Paraffin sections were deparifinize, rehydrated and blocked woith normal serum. Specifin was fixed in 4% formalin for 4 hours. Optimal antigen retrieval with citrate buffer. | | Western Blot: 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6A617 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide, 0.1% BSA. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Secretory Leukocyte Protease Inhibitor purified from sputnum. | | Specificity | Recognizes human secretory leukocyte proteinase inhibitor (SLPI; also known as antileukoprotease or ALP). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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