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Anti -SEL1L (Suppressor of lin-12-like Protein)
Anti -SEL1L (Suppressor of lin-12-like Protein)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IH |
|
| SEL1L (suppressor of lin-12-like protein) is the human ortholog of the C. elegans sel-1 gene, a negative regulator of the lin-12/Notch family of proteins. Human SEL1L is a component of endoplasmic reticulum-associated degradation (ERAD), involved in ubiquitin-dependent degradation of misfolded ER proteins. In addition, SEL1L plays a role in cancer progression. Several studies provided significant evidence that increased SEL1L expression is linked to a decrease in tumor aggressiveness. | | | Catalog # | S0647-10 | | Applications | Suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested. | | Recommended Dilution | Immunohistochemistry: Frozen and paraffin sections. | | Western Blot: 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6D756 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 150mM sodium chloride, pH 7.4, 0.02% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant human SEL1L. | | Specificity | Recognizes human SEL1L isoforms < 88kD. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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