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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -SEL1L (Suppressor of lin-12-like Protein)

Anti -SEL1L (Suppressor of lin-12-like Protein)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH
SEL1L (suppressor of lin-12-like protein) is the human ortholog of the C. elegans sel-1 gene, a negative regulator of the lin-12/Notch family of proteins. Human SEL1L is a component of endoplasmic reticulum-associated degradation (ERAD), involved in ubiquitin-dependent degradation of misfolded ER proteins. In addition, SEL1L plays a role in cancer progression. Several studies provided significant evidence that increased SEL1L expression is linked to a decrease in tumor aggressiveness.
Catalog #S0647-10
ApplicationsSuitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionImmunohistochemistry: Frozen and paraffin sections.
Western Blot: 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D756
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 150mM sodium chloride, pH 7.4, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human SEL1L.
SpecificityRecognizes human SEL1L isoforms < 88kD. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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