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You are here:Home » Antibodies » Abs to Ubiquitin » Anti -SENP8 (Sentrin-specific Protease 8, Sentrin/SUMO-specific Protease SENP8, Protease, Cysteine 2, NEDD8-specific Protease 1, Deneddylase-1, DEN1, NEDP1, PRSC2, FKSG8)

Anti -SENP8 (Sentrin-specific Protease 8, Sentrin/SUMO-specific Protease SENP8, Protease,
Cysteine 2, NEDD8-specific Protease 1, Deneddylase-1, DEN1, NEDP1, PRSC2, FKSG8)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
SENP8, is a novel cysteine protease which belongs to the ULP family of deubiquitinases. ULP family members consist of a C-terminal core catalytic domain and N-terminal extensions determining substrate specificity. SENP8, a 24kD protein, plays a major role in regulating NEDD8 pathway. It processes preNEDD8 to its mature form and deconjugates NEDD8 from substrates such as Cullins and p53. SENP8 may play a role in preventing accumulation of hyper-neddylated cullin and maintaining the level of mono-neddylated cullin that is thought to increase the efficiency of ubiquitination by SCF ubiquitin ligases.
Catalog #S0747-01B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 0.1-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa196-211 of human SENP8.
SpecificityRecognizes human SENP8. Species sequence homology: mouse, rat, canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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