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You are here:Home » Antibodies » Abs to Protease Inhibitors » Anti -SERPING1 (Serine/Cysteine Proteinase Inhibitor, Clade G, Member 1, Complement C1 Inhibitor, C1-INH, HAE1, HAE2)

Anti -SERPING1 (Serine/Cysteine Proteinase Inhibitor, Clade G, Member 1, Complement C1
Inhibitor, C1-INH, HAE1, HAE2)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP
As a member of the serpin superfamily of serine protease inhibitors, SERPING1 is the physiological inhibitor of activated C1r and C1s, two serine proteases involved in the classical complement pathway. In addition, it inhibits plasma kallikrein and coagulation factor XIIa, two serine proteases involved in the processing of kininogen to release bradykinin. Therefore, it plays an important role in regulating activation of both the complement and contact systems (1). SERPING1 deficiency results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa (2). The deduced amino acid sequence of human Serpin G1 precursor consists of 500 residues with a signal peptide. The mature protein of 478 amino acid residues is heavily glycosylated (1).
Catalog #S1000-78G1
ApplicationsSuitable for use in Direct ELISA, Western Blot and Immunoprecipitation. Other applications have not been tested.
Recommended DilutionsWestern Blot: 1ug/ml
Immunoprecipitation: 25ug/ml to immunoprecipitate from conditioned cell culture medium spiked with human SERPINGG1.
Optimal dilutions should be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No7H118
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman plasma-derived SERPING1.
SpecificityRecognizes human SERPING1. In Western Blot, does not crossreact with recombinant human SERPINA1, -A3, -A4, -A5, -C1, -D1, -E2 or -F1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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