Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Serotonin Receptors » Anti -Serotonin Receptor 1D (5-Hydroxytryptamine 1D Receptor, 5-Hydroxytryptamine Serotonin Receptor 1D, 5HT1D, 5-HT-1D, 5-HT-1D-alpha, G-Protein Coupled Receptor 14, GPCR14, HT1DA, HTR1DA, HTRL, RDC4)

Anti -Serotonin Receptor 1D (5-Hydroxytryptamine 1D Receptor, 5-Hydroxytryptamine
Serotonin Receptor 1D, 5HT1D, 5-HT-1D, 5-HT-1D-alpha, G-Protein Coupled Receptor 14,
GPCR14, HT1DA, HTR1DA, HTRL, RDC4)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems (1,2). The 5-HT1D (formerly known as 5-HT1Da) receptor has 63% overall structural homology with the 5-HT1B receptor and a 77% amino acid sequence homology in the seven transmembrane domains (3). In situ hybridization studies have detected highest level of mRNA in primary olfactory cortex, accumbens nucleus, caudate putamen, lateral mammilary nucleus and medial vestibular nucleus (4). The presence of relatively high levels of 5-HT1D mRNA in the locus coeruleus suggest that, when expressed on nerve terminals, this receptor could modulate the release of catecholamines. The 5-HT1D receptor may function as an autoreceptor. Like 5-HT1B receptors, 5-HT1D receptors also appear to act as heteroreceptors. Acting on the 5-HT1D receptors, 5-HT appears to inhibit release of glutamate from rat cerebellar synaptosomes and acetylcholine from guinea pig hippocampal synaptosomes (5). It has been suggested that neurogenic inflammation and nociceptive activity within trigemino- vascular afferents. Endothelium-dependent relaxation in the pig coronary artery has been claimed to be mediated by 5-HT1D receptors (6). Like other members of the 5-HT1 family, 5-HT1D receptors are negatively coupled to adenylate cyclase.
Catalog #S1001-15D4
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Positive Control human, mouse, or rat brain
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenThis antibody was generated by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 1-18 and 251-267 of rat 5-HT1DR (Genbank accession no. NP_036984) (7).
SpecificityA 40kD band is detected. Species Crossreactivity: Human, Mouse, Rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links