Anti -Serotonin Receptor 2C (HTR2C, 5-hydroxytryptamine Receptor 2C, 5-HT-2C, 5-HT2C,
5-HTR2C, 5-hydroxytryptamine Receptor 1C, 5-HT-1C, 5-HT1C, HTR1C)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| Serotonin Receptor 2C (5-HT2C) activates phospholipase C, resulting in a transient increase in intracellular calcium and activation of protein kinase C. Mutant mice lacking functional 5-HT2C receptor are overweight due to abnormal feeding behavior and are prone to epileptic seizures. Therefore, agonists of the 5-HT2C receptor such as m-chlorophenylpiperazine (mCPP) may be potential drugs for the treatment of obesity. However, mCPP also has unpleasant side effects such as anxiety and nausea in humans. Most psychedelic drugs bind 5-HT2A and 5-HT2C receptors, and their hallucinogenicity correlates with binding affinity. Expression of the 5-HT2C receptor has been reported predominantly in brain, but also in spinal cord and lung. ESTs have been isolated from human, mouse, and rat brain libraries. | | | Catalog # | S1001-18G | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:3000 | | Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in 0.1M Tris-glycine, pH 7.0, 0.01% thimerosal, 10% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to human HTR2C conjugated to KLH. | | Specificity | Recognizes human HTR2C. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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