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You are here:Home » Antibodies » Abs to Serotonin Receptors » Anti -Serotonin Receptor 1B (5-Hydroxytryptamine (Serotonin) Receptor 1B, 5-Hydroxytryptamine Receptor 1B, 5ht1b, 5-HT1B, 5-HT-1B, HTR1B)

Anti -Serotonin Receptor 1B (5-Hydroxytryptamine (Serotonin) Receptor 1B,
5-Hydroxytryptamine Receptor 1B, 5ht1b, 5-HT1B, 5-HT-1B, HTR1B)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems (1). Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase (2). Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum (3,4). The in situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei (5).
Catalog #S1001-19B1
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman, mouse, or rat brain
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by Protein G affinity Chromatography.
ImmunogenSynthetic peptides corresponding to aa8-26 and 263-278 of rat 5-HT1BR (Accession number P28564) (6).
SpecificityRecognizes rat 5-HT1BR. Species Crossreactivity: human and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names5-HT1B Receptor, 5-HT-1D-beta, 5-HT1DB, HTR1D2, HTR1DB, S12, Serotonin 1D beta Receptor


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