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You are here:Home » Antibodies » Abs to Serotonin Receptors » Anti -Serotonin Receptor 3A (5-HT3A, HTR3A, 5-Hydroxytryptamine (Serotonin) Receptor 3A, 5-HT-3, 5-HT3R, HTR3, 5HT3 Serotonin Receptor, Serotonin-gated Ion Channel Receptor)

Anti -Serotonin Receptor 3A (5-HT3A, HTR3A, 5-Hydroxytryptamine (Serotonin) Receptor 3A,
5-HT-3, 5-HT3R, HTR3, 5HT3 Serotonin Receptor, Serotonin-gated Ion Channel Receptor)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
Catalog #S1001-19L
ApplicationsSuitable for use in ELISA and Western Blot. Other applications have not been tested.
Recommended DilutionWestern Blot: 0.3-1ug/ml. Approximately 55kD ban observed using human colon lysates (calculated MW is 55.3kD according to NP_000860.1). A minor band of unknown identity was also consistently observed at 200kD. This band was successfully blocked by incubation with the immunizing peptide.
Peptide ELISA (titer) 1:28,000
Optimal dilutions to be determined by the researcher.
Positive Control Human Colon lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide, CGPQDFEKSPRDR, representing the internal region of the human protein according to NP_998786.1; NP_000860.1.
SpecificitySpecies Crossreactivity: Human. Other species not tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names5-HT3A, HTR3A, 5-Hydroxytryptamine (Serotonin) Receptor 3A, 5-HT-3, 5-HT3R, HTR3, 5HT3 Serotonin Receptor, Serotonin-gated Ion Channel Receptor


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