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You are here:Home » Antibodies » Abs to Serotonin Receptors » Anti -Serotonin Receptor 3B (HTR3B, 5-hydroxytryptamine (serotonin) receptor 3B, 5-HT-3B, 5-HT3B, 5-HT-3B, 5-hydroxytryptamine receptor 3B, HTR3B)

Anti -Serotonin Receptor 3B (HTR3B, 5-hydroxytryptamine (serotonin) receptor 3B, 5-HT-3B,
5-HT3B, 5-HT-3B, 5-hydroxytryptamine receptor 3B, HTR3B)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems . The 5-HT3 receptors are distinguished from other 5-HT receptors by their structure and function. 5-HT3 receptors span the membrane only four times and are ligand-gated, cation-selective ion channels that mediate neuronal excitation and exocytotic release of neurotransmitters within the peripheral and central nervous systems. Functional studies done on isolated tissues have revealed heterogeneity of this receptor. The human 5-HT3R-As cDNA contains an open reading frame of 1434 base pairs predicting a 23-residue signal peptide and a mature receptor subunit of 455 amino acids. The human subunit exhibits 85% and 84% amino acid sequence identity to the mouse and rat receptors, respectively. Anti-5-HT3R polyclonal antibody shows immunoreactivity in the forebrain (olfactory regions, hippocampal formation and amygdala), sensory and motor nuclei of brainstem and spinal cord.
Catalog #S1001-19N
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:16,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by affinity chromatography.
ImmunogenPeptide with sequence C-SNYLQTQDQTDQQE, from the internal region (near C-terminus) of human Serotonin Receptor 3B/Htr3b (NP_006019.1).
SpecificityRecognizes human Serotonin Receptor 3B/Htr3b.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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