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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified IH

The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmaceutical modulation of serotonin receptors (5-HT3 and 5-HT4 subtypes). At least 9 isoforms have been described, which differ in length and composition of their intracellular C- termini after a common splicing site. 5-HT4 receptor expression has been documented primarily in the brain, and in colon, heart, and vessel.
Catalog #	S1001-20
Applications
	Suitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended Dilution	Immunohistochemistry: Formalin fixed paraffin embedded tissues.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.4, 0.01% sodium azide.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptidecorresponding to the C-terminus of human Serotonin Receptor 4 (KLH).
Specificity	Recognizes human Serotonin Receptor 4. Species Crossreactivity
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.