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You are here:Home » Antibodies » Abs to Serotonin Receptors » Anti -Serotonin Receptor 4 (5-Hydroxytryptamine 4 Receptor, 5-Hydroxytryptamine-4 Receptor, 5-HT4R, 5-Hydroxytryptamine Receptor 4, 5-Hydroxytryptamine Serotonin Receptor 4, 5HT4, 5-HT-4, 5-HT4, Cardiac 5-HT4 Receptor, HTR4, Serotonin 5-HT4 Receptor)

Anti -Serotonin Receptor 4 (5-Hydroxytryptamine 4 Receptor, 5-Hydroxytryptamine-4
Receptor, 5-HT4R, 5-Hydroxytryptamine Receptor 4, 5-Hydroxytryptamine Serotonin Receptor
4, 5HT4, 5-HT-4, 5-HT4, Cardiac 5-HT4 Receptor, HTR4, Serotonin 5-HT4 Receptor)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop. 5-HT4 receptor expression has been documented primarily in the brain, and in colon, heart, and vessel. An EST has been isolated from a human cancerous nerve library.
Catalog #S1001-20C
ApplicationsSuitable for use in Immunohistochemistry (paraffin-embedded sections). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by immunoaffinity chromatography.
Immunogen3rd cytoplasmic domain of human.
SpecificitySpecies Crossreactivity: Human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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