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You are here:Home » Antibodies » Abs to Glucose Transporters » Anti -SGLT-1 (Sodium Glucose Transporter 1)

Anti -SGLT-1 (Sodium Glucose Transporter 1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
The kidneys play a major role in the regulation of glucose levels. Kidneys filter approx. 180g of glucose per day from the blood, and this is mostly reabsorbed back into the blood in the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, sodium glucose co-transporters (SGLT), in the brush-border membrane and then it is transported out of the cell across the basolateral membranes bya facilitated sugar transporter
(GLUTs). At least 3 members of SGLTs (SGLT1-3) have been cloned and characterized from various species. Individual members of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT1-3 genes code for protein of approx 659-672 residues (75kD). Both N and C termini are predicted to be extracellular. There is approx 60-70% homology between SGLT1-3. SGLTs transport a-methyl-D-glucoside (a-MDG), a non metabolized model substrate, in Na-dependent manner. SGLT1 does not discriminate a-MDG, glucose, and galactose. SGLT2/3 do not transport D-galactose efficiently.
Catalog #S1010-86B
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsELISA: 0.5-1ug/ml
Western Blot: 1:10ug/ml (ECL) ~70-77kD.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 month after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa19near the extracellular domain #4 of mouse/rabbit SGLT-1, conjugated to KLH
SpecificityRecognizes mouse SGLT-1. Species Sequence Homology: rabbit, bovine and sheep; 100%, equine and rat; 94%, porine; 89%, chicken; 86%, human; 84%. Mouse SGLT-3, SGLT-4a/4b; 84%, human SAAT/SGLT-3; 78%, human and rat SGLT-2; 63%
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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